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这项DNA测试可预测5岁儿童成年后是否会出现肥胖

本站发布时间:2025-08-02 11:00:18
注:部分名称可能翻译不全,如有问题可联系15163559288@163.com

通过利用超过五百万人群的遗传数据,一个国际研究团队创建了一种名为多基因风险评分(PGS)的遗传检测方法,可在儿童早期预测成年期肥胖症。这一发现有助于识别具有较高肥胖遗传风险的儿童和青少年,他们可能受益于更早启动的针对性预防策略,如生活方式干预。

哥本哈根大学诺和诺德基金会基础代谢研究中心(CBMR)助理教授、本研究首席作者Roelof Smit表示:"该评分的强大之处在于其能在五岁之前——远早于其他风险因素在儿童后期开始影响体重时——预测儿童是否可能在成年期发展为肥胖症。在此阶段进行干预可能产生巨大影响。"该研究成果发表于《自然·医学》期刊。

本研究源于人体测量学特征遗传调查(GIANT)联盟,该国际协作组织由人类遗传学研究人员组成,致力于研究身高、体质量指数等人体测量学特征的遗传结构。研究合作方包括消费级遗传学与研究公司23andMe, inc.,并汇集了全球500个机构的600多位科学家的贡献。

预测效能两倍于次优检测方法

基因组中的细微变异会显著影响健康。目前已发现数千种增加肥胖风险的基因变异,例如作用于大脑影响食欲的变异。多基因风险评分如同计算器,综合个体携带的不同风险变异效应并提供总体评分。

为构建该评分体系,科学家们利用了五百多万人的遗传数据——这是迄今规模最大、多样性最丰富的遗传数据集。随后,他们在超过50万人群的生理与遗传特征数据集上测试了该肥胖预测新模型。结果显示,新评分预测个体肥胖风险的效能是此前最优方法的两倍。

 

哥本哈根大学CBMR的Ruth Loos教授指出:"这种新型多基因评分实现了预测效能的飞跃式提升,标志着肥胖风险遗传预测的重大突破,使我们更接近临床实用的基因检测。"

遗传并非宿命

科学家们还探究了肥胖遗传风险与饮食运动等生活方式减肥干预效果的关系。他们发现,高遗传风险人群对干预措施反应更显著,但在干预结束后体重反弹也更快。

然而,该新型评分存在局限性:尽管采用了更具全球代表性的基因组数据,其对欧洲血统人群肥胖的预测准确性远高于非洲血统人群。

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Materials provided byUniversity of Copenhagen - The Faculty of Health and Medical Sciences.Note: Content may be edited for style and length.

Journal Reference:

Roelof A. J. Smit, Kaitlin H. Wade, Qin Hui, Joshua D. Arias, Xianyong Yin, Malene R. Christiansen, Loic Yengo, Michael H. Preuss, Mariam Nakabuye, Ghislain Rocheleau, Sarah E. Graham, Victoria L. Buchanan, Geetha Chittoor, Marielisa Graff, Marta Guindo-Martínez, Yingchang Lu, Eirini Marouli, Saori Sakaue, Cassandra N. Spracklen, Sailaja Vedantam, Emma P. Wilson, Shyh-Huei Chen, Teresa Ferreira, Yingjie Ji, Tugce Karaderi, Kreete Lüll, Moara Machado, Deborah E. Malden, Carolina Medina-Gomez, Amy Moore, Sina Rüeger, Masato Akiyama, Matthew A. Allison, Marcus Alvarez, Mette K. Andersen, Vivek Appadurai, Liubov Arbeeva, Eric Bartell, Seema Bhaskar, Lawrence F. Bielak, Joshua C. Bis, Sailalitha Bollepalli, Jette Bork-Jensen, Jonathan P. Bradfield, Yuki Bradford, Caroline Brandl, Peter S. Braund, Jennifer A. Brody, Ulrich Broeckel, Kristoffer S. Burgdorf, Brian E. 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