研究表明，天然甜味成分莫诺苷V（Mogroside V）对耐药性胰腺癌展现出显著抑制作用。这种三萜类化合物从罗汉果中提取，具有高甜度、低热量的特性。其抗肿瘤作用机制包括：(1) **诱导细胞凋亡与周期

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Jun Saito, Nobuyuki Onishi, Juntaro Yamasaki, Naoyoshi Koike, Yukie Hata, Kiyomi Kimura, Yuji Otsuki, Hiroyuki Nobusue, Oltea Sampetrean, Takatsune Shimizu, Shogo Okazaki, Eiji Sugihara, Hideyuki Saya.Benzaldehyde suppresses epithelial-mesenchymal plasticity and overcomes treatment resistance in cancer by targeting the interaction of 14-3-3ζ with H3S28ph.British Journal of Cancer, 2025; DOI:10.1038/s41416-025-03006-4